Lung metastasis 21 years after initial diagnosis of osteosarcoma: a case report
Lung metastasis 21 years after initial diagnosis of osteosarcoma: a case report
Journal of Medical Case Reports 2009, 3:9298
Published: December 2009
Published: December 2009
Abstract
Introduction:
To the best of our knowledge, this case report describes the longest disease-free interval between primary diagnosis and metastatic recurrence of an osteosarcoma.
Case presentation:
A 35-year-old Caucasian American man presented with asymptomatic lung metastases 21 years after being diagnosed and treated for lower extremity osteosarcoma. He underwent curative lung resection, but 2 years thereafter developed metastatic disease in the scapula and tibia and, after resection and chemotherapy, is in remission 1 year later.
Conclusion:
This case highlights the importance of long follow-up periods and continued surveillance of osteosarcoma patients after initial curative treatment.
Introduction
Osteosarcoma is the third most common cancer in adolescence, after lymphomas and brain tumors. One-third of patients who present with osteosarcoma will have recurrent disease. Within the recurrent disease group, 95% of relapses occur within the first 5 years, with the lung as the most common site of metastases. Reported relapses beyond 10 years are rare in the literature. We describe the case of a 35-year-old man who presented with lung metastasis 21 years after undergoing surgical resection and adjuvant chemotherapy for osteosarcoma of the femur. The patient underwent a curative resection. Histological studies described this calcified lesion as osteosarcoma, thereby confirming, to the best of our knowledge, the longest known disease-free interval to metastatic recurrence reported in the English literature. We discuss the relevant clinical knowledge regarding late relapse of osteosarcoma.
Keywords:
lung metastases, pulmonary metastasis, adenocarcinoma lung metastasis, osteosarcoma lung metastasis, thoracic surgery, osteosarcoma chemotherapy, osteosarcoma bone scan, symptoms osteosarcoma,
lung metastases, pulmonary metastasis, adenocarcinoma lung metastasis, osteosarcoma lung metastasis, thoracic surgery, osteosarcoma chemotherapy, osteosarcoma bone scan, symptoms osteosarcoma,
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