Panniculitis in a patient presenting with a pancreatic tumour and polyarthritis: a case report
Panniculitis in a patient presenting with a pancreatic tumour and polyarthritis: a case report
Published: August 2009
Introduction:
Panniculitis is a rare manifestation of pancreatic disease. Rarer still is the association panniculitis, pancreatitic disease and polyarthritis. A literature search revealed less than five cases of pancreatic panniculitis associated with pancreatic tumour and polyarthritis.
Case presentation:
An 84-year-old Caucasian man presented with epigastric pain, weight loss, polyarthritis and multiple discharging nodules. A computed tomography scan revealed a mass in the head of the pancreas. Histology of the cutaneous lesions confirmed the diagnosis of pancreatic panniculitis.
Conclusion:
Pancreatic panniculitis can clinically present in many ways to clinicians across a broad scope of specialties. Knowledge and understanding of the association between panniculitis and polyarthritis with pancreatic disease may aid rapid diagnosis and management.
Introduction
Pancreatic panniculitis is a rare disease involving fat necrosis in the panniculus in association with pancreatic disease. The rarity of this condition is best described by Mullin et al. who reported one case of panniculitis out of 893 patients with various pancreatic diseases 1. We report a man presenting with panniculitis, pancreatic tumour and polyarthritis with a fatal outcome. Awareness of the rare skin manifestation observed and the potentially fatal consequences, can guide physicians to rapid diagnosis and management.
Case presentation
An 84-year-old Caucasian man presented with a 4-week history of severe abdominal pain radiating to his back and with haematuria. He was receiving long-term warfarin treatment for atrial flutter and his international normalised ratio on admission was 17.6. He complained of nausea and weight loss, but reported no recent change in bowel habit. On examination, the patient was cachectic and pyrexial. He had epigastric and right upper quadrant tenderness. Of note was swelling of his right carpometacarpal, bilateral thumb and index finger metacarpal joints. Laboratory investigations revealed a white-cell count of 12.6 × 109/L, C-reactive protein of 198 mg/L, gammaglutamyl transpeptidase of 273, raised serum lipase of 17362 U/L and serum amylase of 619 U/L. Chest and abdominal X-rays were normal. The abdominal computed tomography (CT) scan showed a 9 × 8 cm mixed attenuation mass initially thought to represent pancreatic head haematoma (Figure 1). The patient’s warfarin treatment was discontinued and he was managed conservatively with intravenous fluids, analgesia and bed rest. Levels of the tumour markers carcinoembryonic antigen (CEA) and CA19-9 were normal. A follow-up scan 8 weeks later revealed that the mass had not resolved and was now more likely to represent a tumour of the head of the pancreas or a pancreatic pseudocyst. The patient declined an endoscopic ultrasound.
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