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Dr Will Donnellan reviews the challenges in chimeric antigen receptor (CAR) T-cell therapy for acute myeloid leukemia (AML). He also gives us his thoughts on the lack of randomized trials for patients with refractory AML and discusses emerging antibody-based therapies. FILMED AT THE AMERICAN SOCIETY OF HEMATOLOGY (ASH) ANNUAL MEETING 2016, SAN DIEGO, CALIFORNIA, US
Dr Naval Daver discusses the use of nivolimumab and ipilimumab in combination with azacitidine in myelodysplastic syndrome and acute myeloid leukemia. FILMED AT THE AMERICAN SOCIETY OF HEMATOLOGY (ASH) ANNUAL MEETING 2016, SAN DIEGO, CALIFORNIA, US
Michele Baccarani discusses the factors influencing the decision to switch tyrosine kinase inhibitor (TKI) therapy in chronic myeloid leukaemia and the options available for patients who develop the T315I "gatekeeper" mutation. Disclosures: Michele Baccarani has received honoraria from ARIAD, BMS, Novartis and Pfizer for consultancies and speaker fees. FILMED AT THE EUROPEAN HEMATOLOGY...