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Foreword Shaji K Kumar, MD
Shaji K Kumar, MD, is a consultant in the Division of Hematology at Mayo Clinic, and Professor of Medicine in the College of Medicine, Mayo
Clinic, Rochester, Minnesota, US. He is currently the chair of the NCCN panel on multiple myeloma and is the co-chair of the NCI multiple
myeloma steering committee. He is a member of several professional societies, including the American Society of Hematology, American
Society of Clinical Oncology, American Association for Clinical Research, American Society for Blood and Marrow Transplantation, American
Medical Association, Association of Physicians of India, and the European Hematology Association. His work has appeared in many peer
reviewed journals such as Lancet Oncology, Journal of Clinical Oncology, Blood Cancer Journal, Leukemia, American Journal of Hematology,
Mayo Clinic Proceedings, Blood, and European Journal of Hematology.
Dr Kumar’s research efforts are directed toward studying novel treatment approaches in myeloma through well-designed clinical trials.
He is principal investigator on multiple phase I, II, and III trials for plasma cell malignancies, which include a combination of Mayo investigator-
initiated trials, industry-sponsored trials, and cooperative group trials. From a translational research standpoint, his laboratory has focused on
development of new agents for plasma cell malignancies, with a particular focus on the tumor microenvironment. Dr Kumar receives ongoing
support for research from the National Institutes of Health and the National Cancer Institute.
W elcome to the spring edition of Oncology & Hematology Review, which features a wide range of articles
covering a variety of therapeutic areas. This edition begins with two topical expert interviews. In the first I
discuss recent advances in the management of multiple myeloma, including the role of minimal residual
disease testing, while Editorial Board member, Ulka Vaishampayan, describes new developments in the therapeutic
landscape of renal cancer, with a focus on the recent pivotal clinical trials involving niovolumab and cabozantinb.
Recent advances in screening have led to a decrease in lung cancer mortality. In an editorial, Ambrose, Copeland,
and King, of the Lung Cancer Alliance, discuss the role of patient advocacy organizations in influencing policy
decisions. Conversely, pancreatic cancer remains a huge clinical challenge with few significant developments in recent
years. Sharlene Gill discusses the inconsistent data from clinical trials of second-line treatments and suggests that
developments in first-line therapies might improve outcomes with post-progression treatment strategies.
The incidence of thyroid cancer is increasing, and while fine needle aspiration cytology is the standard diagnostic
technique, it has limitations including false negative and false positive results. Combining the technique with ultrasound
examination can enhance both clinical assessment and confidence in appropriate cytological sampling. Shaaban,
Metry, and Aspinall review the use of this strategy in a low-volume thyroid centre.
Sarcomas are a rare and heterogeneous group of bone and soft tissue cancers, which have a high incidence of
recurrence and metastases. Therapeutic options are limited, and the use of immunotherapy in these malignancies
is less advanced than in other cancers. Munhoz, Tap, and D’Angelo discuss the development of immune checkpoint
inhibitors for sarcoma patients. Immunotherapy, in particular the use of next generation CD20 antibodies, is also
emerging as a valuable treatment for chemo-refractory chronic lymphocytic leukemia. Sethi and Reddy review the
latest developments in this field. Also on the subject of blood cancers, Betcherman and Punnett describe the poorly
understood phenomenon of paraneoplastic syndromes in children with Hodgkin lymphoma.
Two fascinating articles describe novel aspects of cancer therapy. Fakih presents a discussion on the impact of
primary tumor location on the response of metastatic colorectal cancer to anti-epidermal growth factor receptors and
bevacizumab. In addition, Amey and Karnoub discuss the use of cancer stem cells as therapeutic targets.
We finish with two interesting case reports. Mendoza, Sepúlveda, and Ayres describe a case of monophasic synovial
sarcoma of the infratemporal fossa, together with a review of the literature describing this rare condition. Finally, Kuiper,
Babikian, and Delacruz present an unusual case of cavernous sinus syndrome arising from metastatic prostate cancer.
Oncology & Hematology Review would like to thank all authors who contributed their expertise towards this edition.
We are grateful to our Editorial Board for their ongoing support and guidance. We hope that you find these articles
useful and thought provoking.
TOU CH MED ICA L MEDIA