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Supportive Oncology Figure 1: Change in Cell Count Before and After Treatment A


5,000 10,000 15,000 20,000 25,000 30,000


0 Control SP + CRH B 28,233 +43% 16,037


5,000 10,000 15,000 20,000 25,000 30,000


0 SP + CRH SP + CRH + Evaux thermal water


A: Cell count statistically increased after stimulation by substance P (SP) + corticotrophin-releasing hormone (CRH) compared with control culture. B: Cell count statistically decreased after adding Evaux thermal spring water to cell count stimulated by SP + CRH.


Figure 2: Big Toes Before and After Treatment A


A and B: Left and right big toes before treatment with Evonail Solution


brush. This solution leaves an invisible matt film after a drying time of two to three minutes. From the sixth day after starting applications, the onycholysis was greatly reduced on all nails, and absent on some nails (see Figures 2C and 2D). Only the original pigmentation persisted, although it was reduced. The Evolife response is Evonail film-forming solution based on mineral elements contained in Evaux thermal spring water, which is presented in a 12ml glass bottle with an applicator brush. Drying time is two to three minutes (two applications per day).


Case Report 2 B C


C and D: Left and right big toes after topical treatment twice a day with Evonail Solution (sixth day)


The second case report illustrates the acneiform rashes sometimes induced by new targeted chemotherapies and the result obtained with the same active components formulated in a spraying solution. A 54-year-old man presented with a folliculitis-type eruption on the face and torso against an erythemateous background (see Figure 3A). Acneiform eruptions (folliculitis) caused by these molecules are frequently reported in the literature. He had been treated for cancer of the tongue with pulmonary metastases by the combination of cisplatinum and cetuximab (Erbitux®) for one month, after nine months of chemotherapy combining carboplatine and fluorouracil (5-FU). In order to reduce these cutaneous symptoms, Evozac® Solution Spray was sprayed morning and night on all affected areas of the face. This solution contains neither grease nor alcohol. Evozac Solution Spray is formulated from mineral elements contained in Evaux thermal spring water (lithium, manganese, strontium). Seven days after commencing applications, the folliculitis was greatly reduced over the entire face (see Figure 3B). This result was maintained and improved after 26 days of applying Evozac (see Figure 3C). No intolerance to Evozac Solution Spray was reported by the patient during the application period.


D


Cetuximab (Erbitux), an epidermal growth factor (EGF) receptor inhibitor, is a frequently used chemotherapeutic agent, especially in the treatment of ear, nose and throat (ENT) cancers expressing this receptor. The introduction of an effective product without side effects for topical use in a rapid timespan of a few days for inflammatory lesions observed during chemotherapy offers the patient a significant functional and aesthetic benefit by improving his or her quality of life and contributing to better adherence to the chemotherapy regime.


Case Report 3


This case report summarises the clinical benefits obtained after using the Evoskin spray, which is specially formulated for hand–foot syndrome experienced during chemotherapy with cetuximab. A 49-year-old man


14 EUROPEAN ONCOLOGY & HAEMATOLOGY 28,233


18,316 –35.1%


Cells/ml


Cells/ml


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