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Breast Magnetic Resonance Imaging of Multicentric, Multifocal and Bilateral Cancer


but did not fully answer whether pre-operative breast MRI adds benefit because recurrence and overall survival rates were not examined.


unnecessary,63 Specifically in terms of the recurrence rate, Fisher et al.27 obtained


better results: 1.2% recurrences in patients with a pre-surgical MRI versus 6.8% in women without it. The rate of undetected contralateral carcinomas in the follow-up was 1.7% in women with pre-surgical MRI versus 4% of women without MRI. Nevertheless, Drew et al.64


recurrence rate, and Solin et al.59


did not see any impact of pre-surgical MRI on the local did not observe any difference in


the incidence of contralateral carcinoma in patients with or without pre-surgical MRI. All these studies indicate that there is still no consensus about the impact of MRI on recurrence rate. On the other hand, the new techniques of minimally invasive treatment, such as radiofrequency, microwaves, high-intensity focused ultrasound and


1. Ellis IO, Schnitt SJ, Sastre-Garau X, et al., Invasive breast carcinoma. In: Tavassoli FA, Deville P (eds), World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs, 1st edn, Lyon: IARC Press, 2003.


2. Mosquera Oses J, Controversies in breast cancer screening, Radiología, 2010;52:3–6.


3. Sardanelli F, Giuseppetti GM, Panizza P, et al., Sensitivity of MRI versus mammography for detecting foci of multifocal, multicentric breast cancer in fatty and dense breasts using the whole-breast pathologic examination as a gold standard, Am J Roentgenol, 2004;183:1149–57.


4. American College of Radiology (ACR). ACR BI-RADS®- Mammography, 4th edn. In: ACR Breast Imaging Reporting and Data System, Breast Imaging Atlas, Reston, VA: American College of Radiology, 2003.


5. Martín Díez F, Controversies in breast sonography, Radiología, 2010;52:22–5.


6. Stavros AT, Thickman D, Rapp CL, et al., Solid breast nodules: use of sonography to distinguish between benign and malignant lesions, Radiology, 1995;196:123–34.


7. Berg WA, Gutierrez L, NessAiver MS, et al., Diagnostic accuracy of mammography, clinical examination, US and MR Imaging in preoperative assessment of breast cancer, Radiology, 2004;233:830–49.


8. American College of Radiology (ACR). ACR BI-RADS®- Ultrasound, 4th edn. In: ACR Breast Imaging Reporting and Data System, Breast Imaging Atlas, Reston, VA: American College of Radiology, 2003.


9. Berg WA, Gilbreath PL, Multifocal and multicentric cancer: whole-breast US in preoperative evaluation, Radiology, 2000;214:59–66.


10. Moon WK, Noh DY, Im JG, Multifocal, multicentric, and contralateral breast cancers: bilateral whole-breast US in the preoperative evaluation of patients, Radiology, 2002;224:569–76.


11. Caramella T, Chapellier C, Ettore F, et al., Value of MRI in the surgical planning of invasive lobular breast carcinoma: a prospective and retrospective study of 57 cases. Comparison with physical examination, conventional imaging and histology, Clin Imaging, 2007;31:155–61.


12. Lalonde L, David J, Trop I, Magnetic resonance imaging of the breast: current indications, Can Assoc Radiol J, 2005;56:301–8.


13. Balu-Maestro C, Chapellier C, Bleuse A, et al., Imaging in evaluation of response to neoadjuvant breast cancer treatment benefits of MRI, Breast Cancer Res Treat, 2002;72:145–52.


14. Kim HJ, Im YH, Han BK, et al., Accuracy of MRI for estimating residual tumour size after neoadjuvant chemotherapy in locally advanced breast cancer: relation to response patterns on MRI, Acta Oncol, 2007;46:996–1003.


15. Camps Herrero J, Controversies in breast MRI, Radiología, 2010;52:26.


16. Vénat-Bouvet L, Desfougères M, Aubard Y, et al., MRI evaluation of primary chemotherapy response in breast cancer, Bull Cancer, 2004;91:721–8.


17. Kwong MS, Chung GG, Horvath LJ, et al., Postchemotherapy MRI overestimates residual disease compared with histopathology in responders to neoadjuvant therapy for locally advanced breast cancer, Cancer J, 2006;12:212–21.


18. Kneeshaw PJ, Lowry M, Manton D, et al., Differentiation of benign from malignant breast disease associated with screening detected microcalcifications using dynamic contrast enhanced magnetic resonance imaging, Breast, 2006;15:29–38.


19. Morrogh M, Morris EA, Liberman L, et al., The predictive value of ductography and magnetic resonance imaging in the management of nipple discharge, Ann Surg Oncol, 2007;14:3369–77.


20. Linda A, Zuiani C, Bazzocchi M, et al., Borderline breast lesions diagnosed at core needle biopsy: can magnetic resonance mammography rule out associated malignancy?


partial breast radiotherapy instead of radiotherapy of the whole breast, will require a very accurate technique for staging – and that technique will certainly be MRI.15


Conclusion


Breast MRI is the most sensitive imaging modality for the detection of invasive carcinoma3,11,27,29,37


remainder of the conventional imaging techniques.7,62


and must be evaluated together with the It plays an


essential role in the detection of additional tumour foci, especially in young women with a family history of breast cancer, those with dense breasts and women with primary lobular carcinoma.3,11,27,29,37 MRI can modify the surgical approach in these patients,35,37,48,55,62


Findings in so


radiologists should be aware of false-positives that can lead to unnecessary biopsies or surgeries and more aggressive treatments. The impact of pre-surgical staging MRI on the rate of re-operation, recurrences and survival, remains controversial. n


Preliminary results based on 79 surgically excised lesions, Breast, 2008;17:125–31.


21. Saslow D, Boetes C, Burke W, et al., American Cancer Society guidelines for breast screening with MRI as an adjunct to mammography, CA Cancer J Clin, 2007;57:75–89.


22. The National Comprehensive Cancer Network (NCCN), Breast Cancer Screening and Diagnosis, Practice Guidelines in Oncology v.2.2009.


23. Kuhl C, The current status of breast MR imaging. Part I. Choice of technique, image interpretation, diagnostic accuracy and transfer to clinical practice, Radiology, 2007;244:356–78.


24. Macura KJ, Ouwerkerk R, Jacobs MA, Bluemke DA, Patterns of enhancement on breast MR Images: Interpretation and imaging pitfalls, Radiographics, 2006;26:1719–34.


25. Berg WA, Gutierrez L, NessAiver MS, et al., Diagnostic accuracy of mammography, clinical examination, US and MR imaging in preoperative assessment of breast cancer, Radiology, 2004;233:830–49.


26. American College of Radiology (ACR), ACR BI-RADS®- Magnetic Resonance Imaging, 4th edn. In: ACR Breast Imaging Reporting and Data System, Breast Imaging Atlas, Reston, VA: American College of Radiology, 2003.


27. Fischer U, Zachariae O, Baum F, et al., The influence of preoperative MRI of the breasts on recurrence rate in patients with breast cancer, Eur Radiol, 2004;14:1725–31.


28. Solin LJ, Breast conservation treatment with radiation: an ongoing success story, J Clin Oncol, 2010;28(5):709–11.


29. Van Goethem M, Schelfout K, Dijckmans L, et al., MR mammography in the pre-operative staging of breast cancer in patients with dense breast tissue: comparison with mammography and ultrasound, Eur Radiol, 2004;14:809–16.


30. Mann RM, The effectiveness of MR imaging in the assessment of invasive lobular carcinoma of the breast, Magn Reson Imaging Clin North Am, 2010;18(2):259–76, ix.


31. Lim HI, Choi JH, Yang JH, et al., Does pre-operative breast magnetic resonance imaging in addition to mammography and breast ultrasonography change the operative management of breast carcinoma?, Breast Cancer Res Treat, 2010;119:163–7.


32. Pengel KE, Loo CE, Teertstra HJ, et al., The impact of preoperative MRI on breast-conserving surgery of invasive cancer: a comparative cohort study, Breast Cancer Res Treat, 2009;116(1):161–9.


33. Houssami N, Hayes DF, Review of preoperative magnetic resonance imaging (MRI) in breast cancer: should MRI be performed on all women with newly diagnosed, early stage breast cancer? CA Cancer J Clin, 2009;59:290–302.


34. Solin LJ, Counterview: pre-operative breast MRI (magnetic resonance imaging) is not recommended for all patients with newly diagnosed breast cancer, Breast, 2010;19:7–9.


35. Houssami N, Ciatto S, Macaskill P, et al. Accuracy and surgical impact of magnetic resonance imaging in breast cancer staging: systematic review and meta-analysis in detection of multifocal and multicentric cancer, J Clin Oncol, 2008;26:3248–58.


36. Mann RM, Veltman J, Barentsz JO, et al., The value of MRI compared to mammography in the assessment of tumour extent in invasive lobular carcinoma of the breast, Eur J Surg Oncol, 2008;34:135–42.


37. Tillman GF, Orel SG, Schnall MD, et al., Effect of breast magnetic resonance imaging on the clinical management of women with early-stage breast carcinoma, J Clin Oncol, 2002;20:3413–23.


38. Schelfout K, Van Goethem M, Kersschot E, et al., Contrast- enhanced MR imaging of breast lesions and effect on treatment, Eur J Surg Oncol, 2004;30:501–7.


39. Kneeshaw PJ, Turnbull LW, Smith A, Drew PJ, Dynamic contrast enhanced magnetic resonance imaging aids the surgical management of invasive lobular breast cancer, Eur J Surg Oncol, 2003;29:32–7.


40. Bilimoria KY, Cambic A, Hansen NM, Bethke KP, Evaluating


the impact of preoperative breast magnetic resonance imaging on the surgical management of newly diagnosed breast cancers, Arch Surg, 2007;142:441–5, discussion 445–7.


41. Drew PJ, Chatterjee S, Turnbull LW, et al., Dynamic contrast enhanced magnetic resonance imaging of the breast is superior to triple assessment for the pre-operative detection of multifocal breast cancer, Ann Surg Oncol, 1999;6:599–603.


42. Al-Hallaq HA, Mell LK, Bradley JA, et al., Magnetic resonance imaging identifies multifocal and multicentric disease in breast cancer patients who are eligible for partial breast irradiation, Cancer, 2008;113:2408–14.


43. Hollingsworth AB, Stough RG, O’Dell CA, Brekke CE, Breast magnetic resonance imaging for preoperative locoregional staging, Am J Surg, 2008;196:389–97.


44. Siegmann KC, Baur A, Vogel U, et al., Risk-benefit analysis of preoperative breast MRI in patients with primary breast cancer, Clin Radiol, 2009;64:403–13.


45. Pediconi F, Catalano C, Padula S, et al., Contrast-enhanced magnetic resonance mammography: does it affect surgical decision-making in patients with breast cancer?, Breast Cancer Res Treat, 2007;106:65–74.


46. Pediconi F, Catalano C, Roselli A, et al., Contrast-enhanced MR mammography for evaluation of the contralateral breast in patients with diagnosed unilateral breast cancer or high- risk lesions, Radiology, 2007;243:670–80.


47. Sardanelli F, Overview of the role of pre-operative breast MRI in the absence of evidence on patient outcomes, Breast, 2010;19:3–6.


48. Martínez V, Carreira MC, Pérez Y, et al., Effect of preoperative magnetic resonance imaging on the surgical treatment of breast carcinoma, Prog Obstet Ginecol, 2007;50:682–8.


49. Mann RM, Hoogeveen YL, Blickman JG, Boetes C, MRI compared to conventional diagnostic work-up in the detection and evaluation of invasive lobular carcinoma of the breast: a review of existing literature, Breast Cancer Res Treat, 2008;107:1–14.


50. Gundry KR, The application of breast MRI in staging and screening for breast cancer, Oncology (Williston Park), 2005;19:159–69, discussion 170, 173–4, 177.


51. Tendulkar RD, Chellman-Jeffers M, Rybicki LA, et al., Preoperative breast magnetic resonance imaging in early breast cancer: implications for partial breast irradiation, Cancer, 2009;115:1621–30.


52. Pediconi F, Catalano C, Roselli A, et al., The challenge of imaging dense breast parenchyma: is magnetic resonance mammography the technique of choice? A comparative study with x-ray mammography and whole-breast ultrasound, Invest Radiol, 2009;44:412–21.


53. Olivas-Maguregui S, Villaseñor-Navarro Y, Ferrari-Carballo T, et al., Importance of the preoperative evaluation of multifocal and multicentric breast cancer with magnetic resonance imaging in women with dense parenchyma, Rev Invest Clin, 2008;60:382–9.


54. Kuhl C, Kuhn W, Braun M, Schild H, Pre-operative staging of breast cancer with breast MRI: one step forward, two steps back?, Breast, 2007;16:S34–44.


55. Fischer U, Baum F, Luftner-Nagel S, Preoperative MR imaging in patients with breast cancer: preoperative staging, effects on recurrence rates, and outcome analysis, Magn Reson Imaging Clin N Am, 2006;14:351–62, vi.


56. Kuhl CK, Braun M, Magnetic resonance imaging in preoperative staging for breast cancer: pros and contras, Radiologe, 2008;48:358–66.


57. Lehman CD, DeMartini W, Anderson BO, Edge SB, Indications for breast MRI in the patient with newly diagnosed breast cancer, J Natl Compr Canc Netw, 2009;7:193–201.


58. McCaffery KJ, Jansen J, Pre-operative MRI for women with newly diagnosed breast cancer: perspectives on clinician and patient decision-making when evidence is uncertain, Breast, 2010;19:10–2.


59. Solin LJ, Orel SG, Hwang WT, et al., Relationship of breast


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