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Foreword Michele Baccarani
Michele Baccarani trained in medicine, hematology, and oncology at the Universities of Bologna (1966–1979), Paris (1967), and Copenhagenn
(1971). He became professor of Cancer Chemotherapy at the University of Chieti in 1979, then he was appointed professor of hematology
at the Universities of Trieste (1980–1986), Udine (1987–2000), and Bologna (2001–2012), where he was the Head of the Department of
Haematology and Oncology ‘L and A Seràgnoli’ at the S Orsola-Malpighi University Hospital, Bologna, until November 2012. Currently, he is
serving as Chairman of the GIMEMA CML Working Party (formerly the Italian Cooperative Study Group on Chronic Myeloid Leukaemia) and
of the chronic myeloid leukemia (CML) working package of the European LeukemiaNet. He is past-president of both the Italian Society of
Hematology and the Italian Society of Experimental Hematology. Michele Baccarani is first or contributing author of over 600 peer-reviewed
publications in the field of clinical and translational haematology, cell kinetics, stem cells and stem cell transplantation, experimental
chemotherapy, malignant lymphoma, and acute and chronic leukemias, particularly CML.
W elcome to the fall edition of Oncology & Hematology Review, which features a broad range of articles
covering topics of relevance to oncologists and hematologists, as well as the wider medical community.
Included in this edition is an article by Al Dallal on sickle cell trait (SCT). While not a disease in itself, SCT is
associated with a number of clinical conditions including renal disease, which has important implications for global
public health recommendations.
This issue features several articles on solid tumors. High dose interleukin-2 (HD IL-2) has been used in the treatment
of metastatic renal cell carcinoma and metastatic melanoma for over 20 years, but in the era of targeted therapies
and immune checkpoint inhibitors, its role is unclear. Gupta and Agarwal present an overview of its status in current
treatment paradigms and future developments. In addition, an editorial by Kaufman presents a perspective on the role
of HD IL-2 based on recent data from the PROCLAIM registry.
Triple negative breast cancer accounts for up to 20% of all breast cancers diagnosed in the United States. Ballinger
et al. review the current and emerging therapeutic options for this aggressive and hard to treat malignancy. Another
area that has undergone significant recent advances is the treatment of colorectal and anal cancer. Goldberg
highlights the top-ranked presentations from the 2016 Annual American Society of Clinical Oncology (ASCO)
meeting, with a focus on immunotherapy and the site of the primary tumor in gastrointestinal cancers, information
that may soon become integrated into clinical practice.
A case report by Kmeid et al. describes a case of invasive epiglottic aspergillosis mimicking supraglottic laryngeal
carcinoma, in which the diagnosis enabled prompt initiation of antifungal therapy.
This edition features two editorials focus on cancers of the blood. Daver describes exciting new developments in
the treatment of myeloproliferative neoplasms, which have led to prolonged survival and reduced transformation
to leukemia. In addition, Usmani discusses the need for biomarker-driven therapy in multiple myeloma, given its
complexity and heterogeneity.
Oncology & Hematology Review would like to thank all expert authors who contributed towards this edition. A special
thanks goes to our Editorial Board for their continuing support and guidance. We hope that all our readers will find
plenty of interest among these timely and thought-provoking articles. q
TOU CH MED ICA L MEDIA